Archives of Pharmacal Research
- Volume 17 Issue 5
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- Pages.298-303
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Novel Synthesis of Imidazo[1,2-b]Pyrazoles and Their Fused Derivatives
- Sherif, Sherif-M. (Department of Chemistry, Faculty of Science, University of Cairo) ;
- Hussein, Abdel-HaLeem-M. (Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut) ;
- El-kholy, Yehya-M. (Department of Chemistry, Faculty of Science, Helwen University)
- Published : 1994.10.01
Abstract
4-Arylazo-1H-pyrazol-3, 5-idimines 1a-c reacted with bromomalononitrile (2) to yield the corresponding imidazo[1, 2-b]pyrazoles 3a-c. The latter reacted with some active methylene compounds and with .alpha.-cinnamonitriles to afford the corresponding pyrazoloimidazopyridines 6, 8, 9 and 15, respectively. Compounds 3 reacted with each of formic acid, formamide, trichlo-roacetonitrile and with guanidine to yield the corresponding pyrazoloimidazopyrimidines 16-19 respectively.