Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Pathologic Changes in the Rabbit lung Following Single Dose Irradiation

방사선 조사후 관찰한 가토 폐의 병리학적 변화

  • Lee Hyung Sik (Department of Radiation Oncology, Dong-A University, College of Medicine) ;
  • Choi Young Min (Department of Radiation Oncology, Dong-A University, College of Medicine) ;
  • Hur Won Joo (Department of Radiation Oncology, Dong-A University, College of Medicine) ;
  • Jeong Jin Sook (Department of Pathology, Dong-A University, College of Medicine) ;
  • Yuh Young Hyun (Department of Anatomy, Dong-A University, College of Medicine) ;
  • Lee Ki Nam (Department of Diagnostic Radiology, Dong-A University, College of Medicine)
  • 이형식 (동아대학교의과대학 치료방사선과학교실) ;
  • 최영민 (동아대학교의과대학 치료방사선과학교실) ;
  • 허원주 (동아대학교의과대학 치료방사선과학교실) ;
  • 정진숙 (동아대학교의과대학 병리학교실) ;
  • 유영현 (동아대학교의과대학 해부학교실) ;
  • 이기남 (동아대학교의과대학 진단방사선과학교실)
  • Published : 1994.06.01
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Abstract

The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group were sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation,and they progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type II pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.

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