Applied Biological Chemistry
- 제37권4호
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- Pages.287-294
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- 1994
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- 2468-0834(pISSN)
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- 2468-0842(eISSN)
3-(치환(X)-phenyl)-1-(2-furyl)propenone 유도체의 항균활성
Fungicidal Activity of 3-(X-Sub. phenyl)-1-(2-furyl)propenone Derivatives
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Sung, Nack-Do
(Department of Agricultural Chemistry, Chung-nam National University) ;
- Kang, Hee-Deog (Dong-Bang Agrochemical Co.) ;
- Maeng, Joo-Yang (Department of Chemistry, Soonchunhyang University) ;
- Shin, Dong-Rin (Dong-Bang Agrochemical Co.)
- 발행 : 1994.08.31
초록
새로운 3-(4-치환-phenyl)-1-(2-furyl)propenone, 1과 3-(4-치환-phenyl)-1-(2-furyl)-3-thiophenylpropanones, 2 유도체를 합성하여 in vitro에서 잿빛 곰팡이균(Botrytis cineria, BC), 사과 부란병균(Valsa ceratosperma, VC), 마늘 균핵병균(Sclerotium cepivorum, SC) 및 고추 역병균(Phytophthora capsici, PC) 등의 곰팡이 균류에 대한 구조-항균활성 관계(SAR)를 알아보았다. 그 결과, 2보다 1이 비교적 큰 항균활성을 나타내었으며 특히, E(Syn)형의 4-chloro group 치환체, 1d나 비 치환체, 1a가 4가지 균중의 BC균에 대하여 가장 강력한 항균활성
New 3-phenyl-1-(2-furyl)propenones, 1 and 3-phenyl-1-(2-furyl)-3-thiophenyl-propanone, 2 derivatives were synthesized, and their fungicidal activities in vitro against Botrytis cineria (BC), Valsa ceratosperma (VC), Scelerotium cepivorum (SC) and Phytophthora capsici (PC) were investigated using a generalized structure-activity relationship (SAR). The activity of 1 was superior to those of 2, and nonsubstituent, 1a and chloro group substituent, 1d of E (Syn) conformer were the most effective
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