Drug Release Characteristics from Chain-extended and Crosslinked Polypropylene Glycol Hydrogels

폴리프로필렌 글리콜 하이드로겔의 가교도 및 고분자사슬 길이조절에 의한 약물방출특성

Polypropylene glycol (M.W. 4000) was crosslinked and chain-extended by using triisocyanate and diisocyanate to synthesize rubbery and water swellable hydrogels. Model drugs, i.e., sodium salicylate and indomethacin were incorporated in the polymer matrices by swelling loading. The drug release rates of drugs could be regulated by varying the degrees of crosslinking and chain-extension. Whereas, no correlation was observed between the drug release profiles and the swelling behaviours of the matrices. The release of drugs from the matrices was considered to be governed by the mobility and mesh size of the polymer chains in the matrices.