Journal of Pharmaceutical Investigation

  • 제24권4호
  • /
  • Pages.245-250
  • /
  • 1994
  • /
  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지

에칠렌디아민을 배위자로 한 백금(II) 착체의 합성과 항암효과

Synthesis and Antitumor Activity of Pt(ll) Complexes Containing Ethylenediamine

  • 이경태 (경희대학교 약학대학 약화학실) ;
  • 정지창 (경희대학교 의과대학 약리학실) ;
  • 노영수 (경희대학교 약학대학 약화학실)
  • Lee, Kyung-Tae (Department of Medical Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Jung, Jee-Chang (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Roh, Young-Soo (Department of Medical Chemistry, College of Pharmacy, Kyung Hee University)
  • 발행 : 1994.12.20
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초록

An attempt was made to develop new water-soluble antitumor Pt(ll) complexes containing ethylenediamine, and their structures were determined by infrared spectroscopy, $^{13}C$ nuclear magnetic resonance and elemental analysis. Their antitumor activities in vitro against L-1210, p-388 leukemia cells and M-14 melanoma cells were investigated and acceptable antitumor activity was found as compared with cisplatin.

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