Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Controlled Drug Delivery of Ampicillin-Poly(L-lactic acid) Films for the Treatment of Otitis Media

중이염 치료용 암피실린-폴리락트산 필름의 약물방출조건

  • La, Sung-Bum (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Jeong, Seo-Young (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Park, Ki-Dong (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Juhn, Sung-Kyun (Biomedical Research Center, Korea Institute of Science and Technology) ;
  • Goo, Hyun-Chul (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Yang, Seung-Eun (College of Pharmacy, Ewha Woman's University) ;
  • Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
  • 나성범 (한국과학기술연구원 고분자 연구부) ;
  • 정서영 (한국과학기술연구원 고분자 연구부) ;
  • 박기동 (한국과학기술연구원 고분자 연구부) ;
  • 전성균 (한국과학기술연구원 의과학연구센터) ;
  • 구현철 (한국과학기술연구원 고분자 연구부) ;
  • 양승은 (이화여자대학교 약학대학) ;
  • 지웅길 (충남대학교 약학대학)
  • Published : 1994.03.20
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Abstract

A new local drug delivery device to treat otitis media (OM) has been developed. This device consists of a biodegradable poly(L-lactic acid) (PLLA) film containing antibiotic (ampicillin, AMP), which can be placed into the middle ear cavity and release the therapeutic concentration of AMP for prolonged period. Biodegradable films containing AMP (10 w/w%) were prepared by solution casting method using a suspension of the drug in a $PLLA/CH_{2}Cl_{2}$ solution (molecular weight of PLLA, 100,000 (100 K) and 300,000 (300 K), respectively). PLLA-AMP films were characterized by FTIR, DSC, and SEM. In vitro release of AMP from AMP-PLLA films were examined. The release pattern of AMP from AMP-PLLA films remained consistent from 1 day to 14 days, and the release rates of AMP from AMP-100K-PLLA film and AMP-300K-PLLA film were $0.7384\;{\mu}g/ml/day$, $0.4107\;{\mu}g/ml/day$, respectively.

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