Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Antiinflammatory Activity of Ketoprofen Gel

케토프로펜 겔의 함염증작용

  • Tan, Hyun-Kwang (Central Research Laboratories, Il Dong Pharmaceutical Co., Ltd.) ;
  • Chi, Sang-Cheul (College of Pharmacy, Sung Kyun Kwan University) ;
  • Jun, H.Won (College of Pharmacy, University of Georgia)
  • 단현광 (일동제약중앙연구소) ;
  • 지상철 (성균관대학교 약학대학) ;
  • 전흥원 (미국 조지아대학교 약학대학)
  • Published : 1994.03.20
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Abstract

The antiinflammatory and antirheumatic activities of a 3% ketoprofen gel (ID-GEL) were evaluated using carrageenan-induced paw edema method and adjuvant-induced arthritis method, respectively, after its transdermal administration of 50 mg on rat paws in reference to existing transdermal preparations containing 3% ketoprofen and other nonsteroidal antiinflammatory drugs (NSAIDs). The % inhibition of carrageenan-induced edema by ID-GEL was 56.2-65.0%, close to the maximum inhibition obtainable with this model, while the % inhibition by existing 3% ketoprofen gels and other NSAID transdermal preparations were 33.8-47.7% and 18.7-29.2%, respectively. ID-GEL had a pronounced antirheumatic activity in both preventive and curative studies with adjuvant-induced arthritis in rats in respect with the inhibition of edema, arthritis score and weight gain, in reference to existing 3% ketoprofen gel.

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