생약학회지 (Korean Journal of Pharmacognosy)
- 제25권4호통권99호
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- Pages.311-318
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- 1994
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
개바디 뿌리의 쿠마린성분
Coumarins from the Roots of Angelica decursiva-albiflora
- Jung, Nam-Il (College of Pharmacy, Kyung-Hee University) ;
- Yook, Chang-Soo (College of Pharmacy, Kyung-Hee University) ;
- Lee, Hyeong-Kyu (Genetic Engineering Research Institute, KIST)
- 발행 : 1994.12.31
초록
From the root of Angelica decursiva-albiflora Yook, which has been used as a folk medicine for a sedative, analgesic and expectorant, four free coumarins, e.g., decursidin(I), decursin(II), umbelliferone(III) and nodakenetin(IV), and two coumarin glycosides, e.g., nodakenin(V) and decuroside I(VI) were isolate. The cytotoxicity of nodakenin(V) against L-1210 leukemia cells was less effective than cisplatin, but in the nephrotoxicity against rabbit kidney proximal tubular cell nodakenin(V) showed remarkably less nephrotoxicant than cisplatin.
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