Studies on the Biologic Activities of the Constituents of Ailanthi Cortex Radicis (II) -Acute and Renal Toxicity of Chloroform Fraction-

저근백피(樗根白皮) 성분(成分)의 생리활성(生理活性)에 관한 연구(硏究) (II) -클로로포름분획의 급성 및 신장에 대한 독성-

During the serial attempts to identify the chemical and biological characteristics of Ailanthi Cortex Radicis, the root bark of Ailanthus altissima (Simaroubaceae), we find out the serious toxic effect on kidney by chloroform fraction of the methanolic extract of the herb drug. The toxicities were revealed as the increase of urea nitrogen amount in blood and lactate dehydrogenase and ${\gamma}-glutamyltransferase$ activities in urine and the decrease of the concentration of glutathione and both of protein bound and non-protein bound -SH in kidney tissue.