생약학회지 (Korean Journal of Pharmacognosy)
- 제25권1호
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- Pages.59-69
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- 1994
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
마디풀(Polygonum aviculare L.)의 전초가 지질과산화(脂質過酸化) 및 간기능(肝機能)에 미치는 영향
Anti-lipid Peroxidation and Liver Protective Effects of Polygonum aviculare L.
- Lee, Chung-Gi (College of Pharmacy, Kyung-hee University) ;
- Kim, Nam-Jae (East-West Medical Research Institute) ;
- Hong, Nam-Doo (East-West Medical Research Institute) ;
- Kwon, Chang-Ho (College of Pharmacy, Kyung-Hee University)
- 발행 : 1994.03.30
초록
Polygonum aviculare L. was extracted by methanol and then fractionated systematically with solvents and column chromatographic method in order to isolate ingredients with anti-lipid peroxidation and liver protectective effects. Among these fractions, ethylacetate soluble part(MWE) showed the strongest in the anti-lipid peroxidation. Furthermore, the crude subtraction(MWE 4) with Rf value near 0.42, which is separated from MWE by column chromatography using a solvent system, inhibited the lipid peroxidation of rat liver in vitro. Moreover, MWE 4 decreased GOT, GPT and TBA value compared with control and suggested high protective effects against hepatotoxicity induced by carbon tetrachloride in mice. The active compounds in MWE 4 were assumed to be flavonoid glucosides.
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