YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibition of Aromatic L-Amino Acid Decarboxylase (AADC) by Some Phenolic Compounds from Medicinal Plants

천연 페놀성 화합물들의 방향족 아미노산 탈탄산효소 저해작용

  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University)
  • 유시용 (한국화학연구소) ;
  • 한용남 (서울대학교 천연물과학연구소) ;
  • 한병훈 (서울대학교 천연물과학연구소)
  • Published : 1994.12.30
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Abstract

Sixteen kinds of naturally occurring phenolic compounds including 5 stilbenes, 7 flavonoids and 4 anthraquinones were examined in the inhibitory activity against rat liver AADC(aromatic L-amino acid decarboxylase) in vitro, using 5-hydroxytryptophan as a substrate. Three hydroxystilbenes, resveratrol 1, rhapontigenin 3 and piceatanol 5, which were known to be monoamine oxidase A inhibitors, exhibited a significant inhibition against AADC($IC_{50}$=20, 8 and $5\;{\mu}M$, respectively). By the comparison of the activity of each phenolic compound, it was suggested that the 3',4'-dihydroxyphenyl group of stilbenes or flavones was the best pharmacophore for the AADC inhibitory activity.

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