약학회지 (YAKHAK HOEJI)
- 제38권6호
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- Pages.763-769
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Rifampicin과 Ofloxacin에 내성인 Bifidobacterium bifidum 균주의 개발
Development of Bifidobacterium bifidum Strains Resistant to Rifampicin and Ofloxacin
- Chung, Young-Ja (College of Pharmacy, Seoul National University) ;
- Jeon, Myoung-In (College of Pharmacy, Seoul National University) ;
- Kang, Chang-Youl (College of Pharmacy, Seoul National University) ;
- Kim, Byoung-Kak (College of Pharmacy, Seoul National University) ;
- Choi, Eung-Chil (College of Pharmacy, Seoul National University)
- 발행 : 1994.12.30
초록
Bifidobacterium bifidum, one strain of medical preparation being on the market for human intestinal disorders, was sensitive to rifampicin and fluoroquinolones. If this preparation is taken with rifampicin and fluoroquinolones, its therapeutic effect can't be expected. Serial passage of B. bifidum RFR61, which was obtained by MNNG mutation method, on agar with 2-fold minimal inhibitory concentration of ofloxacin produced B. bifidum OFR9 with minimal inhibitory contentrations of fluoroquinolones up to
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