YAKHAK HOEJI (약학회지)
- Volume 38 Issue 6
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- Pages.763-769
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Development of Bifidobacterium bifidum Strains Resistant to Rifampicin and Ofloxacin
Rifampicin과 Ofloxacin에 내성인 Bifidobacterium bifidum 균주의 개발
- Chung, Young-Ja (College of Pharmacy, Seoul National University) ;
- Jeon, Myoung-In (College of Pharmacy, Seoul National University) ;
- Kang, Chang-Youl (College of Pharmacy, Seoul National University) ;
- Kim, Byoung-Kak (College of Pharmacy, Seoul National University) ;
- Choi, Eung-Chil (College of Pharmacy, Seoul National University)
- Published : 1994.12.30
Abstract
Bifidobacterium bifidum, one strain of medical preparation being on the market for human intestinal disorders, was sensitive to rifampicin and fluoroquinolones. If this preparation is taken with rifampicin and fluoroquinolones, its therapeutic effect can't be expected. Serial passage of B. bifidum RFR61, which was obtained by MNNG mutation method, on agar with 2-fold minimal inhibitory concentration of ofloxacin produced B. bifidum OFR9 with minimal inhibitory contentrations of fluoroquinolones up to
Keywords
- Bifidobacterium bifidum;
- Rifampicin;
- Fluoroquinolones;
- Ofloxacin;
- Multi-step mutations;
- Resistant mutant