YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Nephrotoxicity of Pt Complexes as Antitumor Agent

항암활성을 갖는 백금 착체의 합성과 신독성

  • Lee, Keun-Im (College of Pharmacy, Sookmyung Women's University) ;
  • Whang, Kyu-Ja (College of Pharmacy, Sookmyung Women's University)
  • 이근임 (숙명여자대학교 약학대학) ;
  • 황규자 (숙명여자대학교 약학대학)
  • Published : 1994.12.30
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Abstract

Several Pt(II) and Pt(IV) complexes of N,N'-bis(2-hydroxyethyl)ethylenediamine(2-HEen) and N,N'-bis(2-chloroethyl) ethylenediamine(2-CEen) as carrier ligand were prepared. Water soluble Pt complexes were also synthesized by modification of leaving groups. The cytotoxicity of these compounds against leukemia L1210 and P388 cell in vitro were examined. The Pt complexes containing 2-CEen showed more effective cytotoxicity than those containing 2-HEen. Through the nephrotoxicity tests on the primary cultured proximal tubular cells of rabbit kidney and human kidney cells in vitro, Pt complexes with 2-CEen showed higher than those with 2-HEen which were consistent with cytotoxicity but showed very low nephrotoxicity compared with cisplatin. Also the values of BUN and creatinine in serum of Pt complexes were reduced remarkably compared with cisplatin, therefore it can be concluded that new Pt complexes seems to have much lower nephrotoxicity than cisplatin.

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