약학회지 (YAKHAK HOEJI)
- 제38권3호
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- Pages.250-264
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
이온교환수지를 이용한 새로운 오메프라졸 복합체 개발
Development of New Omeprazole-lon Exchange Resin Complex
- Rhee, Gye-Ju (College of Pharmacy, Chungnam National University) ;
- Lee, Ki-Myung (College of Pharmacy, Chungnam National University) ;
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Kim, Eun-Young
(College of Pharmacy, Chungnam National University) ;
- Lee, Chang-Hyun (College of Pharmacy, Chungnam National University) ;
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Hwang, Sung-Joo
(College of Pharmacy, Chungnam National University)
- 발행 : 1994.06.30
초록
Omeprazole(OMZ)-cholestyramine(CHL) and various OMZ-Dowex resin complexes were prepared by reaction between OMZ and activated resins in 0.1N NaOH solution. And their physical properties were tested by means of infrared(IR), differential scaning caloimeter(DSC), X-ray diffraction. Chemical stability of OMZ-CHL was increased markedly compared with OMZ and the decomposition of OMZ-CHL followed the pseudo first-order kinetics and the rate constants were
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