약학회지 (YAKHAK HOEJI)
- 제38권2호
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- Pages.166-173
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
지질과산화 반응과 Free Radical 생성계 효소활성에 미치는 Testosterone의 영향
Effect of Testosterone on Free Radical Generating Enzyme and Lipid Peroxidation
- Huh, Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Shin, Uk-Seob (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Park, Jong-Min (Department of Pharmacy, Yeungnam Medical center)
- 발행 : 1994.04.30
초록
Sex hormones not only regulate external sexual characteristics but several internal biochemical processes. It is well accepted that life-span of female is longer than that of male. Life-span is closely related with aging process in which free radicals are known to be involved. We investigated the effect of testosterone on free radical generating systems and lipid peroxidation based on the sexual difference. Lipid peroxide levels of male and female mouse were increased proportionately with age, especially in male mouse. Increase in enzyme activity of aldehyde oxidase with age was observed in male mouse, while no siginificant change in enzyme activity was found in female mouse. Enzyme activity of xanthine oxidase also showed similar results. It, however, was not significant statistically. Lipid peroxide level and xanthine oxidase type conversion ratio of male and female mouse liver homogenate incubated at