YAKHAK HOEJI (약학회지)
- Volume 38 Issue 1
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- Pages.91-96
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Protoberberine Related Compounds and Their Antifungal Activities
프로토베르베린 관련 화합물합성 및 항균작용
- Kim, Sin-Kyu (College of Pharmacy, Kyung Hee University) ;
- Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
- Chung, Kyung-Hee (College of Pharmacy, Kyung Hee University) ;
- Hwang, Soon-Ho (College of Pharmacy, Kyung Hee University) ;
- Kim, Jae-Hyun (College of Pharmacy, Kyung Hee University)
- Published : 1994.02.28
Abstract
Irradiation of the berberinephenolbetaine [1] effected valence tautamerization to five 8,14-cycloberbine[21, which was converted to the spirobenzylisoquinolines by regioselective C-N bond cleavage A variety of ring systems such as compounds [4], [5] and [6] were introduced by the structural modification of berberinephenolbetaine.
Keywords
- m-chloroperbenzoic acid;
- berberinephenolbetaine;
- benzoyl chloride;
- 8,14-cvcloberbine;
- bis(2-chloroethyl)amine;
- 2-methylaziridine;
- N-C bond cleavage;
- dimethyl acetylenedicarboxylate;
- dimethyl acetylenedicarboxylate