YAKHAK HOEJI (약학회지)
- Volume 38 Issue 1
- /
- Pages.24-30
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Biosynthesis of Nitric Oxide in Pancreatic Tissues
췌조직내 Nitric Oxide의 생합성
-
Kim, Yong-Kee
(Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University)
;
- Nam, Suk-Woo (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
-
Park, Seung-Hee
(Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University)
;
- Yoo, Se-Geun (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
-
Hong, Sung-Youl
(Department of Genetic Engineering, College of Life Science and Natural Resources, Sung Kyun Kwan University)
;
- Lee, Hyang-Woo (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University)
-
김용기
(성균관대학교 약학대학)
;
- 남석우 (성균관대학교 약학대학) ;
-
박승희
(성균관대학교 약학대학)
;
- 유세근 (성균관대학교 약학대학) ;
-
홍성렬
(성균관대학교 유전공학과)
;
- 이향우 (성균관대학교 약학대학)
- Published : 1994.02.28
Abstract
Nitric oxide(NO) synthase was identified and characterized by determining the L-citrulline formed in the NO-Arg pathway in pancreatic tissues. NO synthase activities in chicken pancreas were dependent upon the concentration of L-Arg which is the substrate molecule for the NO synthase, the amount of the enzyme protein used, and linearly on the incubation time. NO synthase in mouse pancreas was found to be constitutive, not induced by lipopolysaccharide treatment. In vitro NO synthase activities of chicken pancreas were inhibited 36%, 21%, 12% and 44% by
Keywords
- Nitric oxide synthase;
- $N^G$-monomethyl-L-arginine;
- $N^G$;
- $N^G$-dimethyl-L-arginine;
- $N^G$;
- $N'^G$-dimethyl-L-arginine