The Korean Journal of Physiology
- Volume 28 Issue 2
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- Pages.181-190
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- 1994
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- 0300-4015(pISSN)
Effects of cGMP on the Contractility and Ca Movement in the Aorta of Normotensive Wistar-Kyoto Rats and Spontaneously Hypertensive Rats
- Park, Hae-Kun (Department of Physiology, College of Medicine, Chungnam National University) ;
- Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Se-Hoon (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Hoe-Suk (Department of Physiology, College of Medicine, Chungnam National University) ;
- Chang, Seok-Jong (Department of Physiology, College of Medicine, Chungnam National University)
- Published : 1994.12.01
Abstract
Endothelium-derived relaxing factor (EDRF) activates guanylate cyclase which mediates the formation of cGMP from GTP in vascular smooth muscle. It is well known that endothelium-dependent relaxation is impaired in spontaneously hypertensive rats (SHR). However, it is still unknown whether the impaired endothelium-dependent relaxation in SHR results from the reduced release of EDRF or from the decrease of vascular response to EDRF. We investigated the effects of cGMP on the contractility and Ca movement in the aorta of SHR and Wistar-Kyoto rats (WKY). The amplitude of the endothelium-dependent relaxation to actylcholine (ACh) was significantly less in SHR than in WKY. L-arginine
Keywords
- Cyclic GMP;
- Sodium nitroprusside;
- Endothelium-dependent relaxation;
- Acetylcholine;
- Spontaneously hypertensive rats