The Korean Journal of Physiology
- 제28권1호
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- Pages.37-50
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- 1994
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- 0300-4015(pISSN)
Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach
- Kim, Sung-Joon (Department of Physiology and Biophysics, Seoul National University College of Medicine) ;
- Jun, Jae-Yeoul (Department of Physiology, Chosun University Medical College) ;
- Choi, Youn-Baik (Department of Surgery, Asan Medical Center, Ulsan University College of Medicine) ;
- Kim, Ki-Whan (Department of Physiology and Biophysics, Seoul National University College of Medicine) ;
- Kim, Woo-Gyeum (Department of Physiology and Biophysics, Seoul National University College of Medicine)
- 발행 : 1994.06.30
초록
Synthetic potassium channel openers (KCOs) are agents capable of opening K-channels in excitable cells. These agents are known to have their maximal potency in the smooth muscle tissue, especially in the vascular smooth muscle. Much attention has been focused on the type of K-channel that is responsible for mediating the effects of KCOs. As the KCO-induced changes are antagonized by glibenclamide, an