Restorative Dentistry and Endodontics

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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A STUDY ON THE CYTOTOXICITY OF THE INCUBATED RESIN SOLUTION

레진 배양액의 세포독성에 관한 연구

  • Im, Mi-Kyung (Dept. of Conservative Dentistry, College of Dentistry, Wonkwang University) ;
  • Kim, Eun-Chul (Dept. of Oral Pathology, College of Dentistry, Wonkwang University) ;
  • Yoo, Soo-Kyung (Dept. of Oral Microbiology, College of Dentistry, Wonkwang University) ;
  • Kim, Kang-Ju (Dept. of Oral Microbiology, College of Dentistry, Wonkwang University)
  • 임미경 (원광대학교 치과대학 치과보존학교실) ;
  • 김은철 (원광대학교 치과대학 구강병리학교실) ;
  • 유수경 (원광대학교 치과대학 구강미생물학교실) ;
  • 김강주 (원광대학교 치과대학 구강미생물학교실)
  • Published : 1993.09.10
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Abstract

To know the in vitro and the in vivo cytotoicity of resin solution, resin solution was applied to cultured fibroblast and was injected into the mouse. The cytotoxic effect of resin solution was measured by MIT assay and in vivo cytotoxicity was examined after Hematoxylin and Eosin staining. The cell activity of resin solution in the concentration of 50% was significantly decreased compared to control group and 5 % group. In histopathologic study of resin solution, there were severe inflammatory cell infiltration, mild interstitial edema, trace hemorrhage, and moderate or severe muscle destruction in resin injected group. These results suggested that there might be some differences between the cell viability of fibroblast and in vivo cell cytotoxicity. Further study is needed to clarify the cytotoxicity by direct implanting of resin mass.

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