Journal of Periodontal and Implant Science
- Volume 23 Issue 1
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- Pages.145-158
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- 1993
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
THE EFFECTS OF HONOKIOL AND MAGNOLOL ON THE ANTIMICROBIAL, BACTERIAL COLLAGENASE ACTIVITY, CYTOTOXICITY AND CYTOKINE PRODUCTION
Magnolol과 Honokiol이 항균, 교원질 분해효소, 세포독성 및 Cytokine생산에 미치는 영향
- Jang, Beom-Seok (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Son, Seong-Heai (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Chung, Chong-Pyoung (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Bae, Ki-Hwan (College of Pharmacy, Chung nam National University)
- Published : 1993.04.30
Abstract
The oral microbiota such as P. gingivalis, P. intermedia and A. actinomycetemcomitans play a primary role in the initiation and progression of the periodontal disease. The purpose of this study was to evaluate the antimicrobial effects and inhibitory effects of honokiol and magnolol on the bacterial collagenase activity, cytotoxicity and cytokine production of periodontopathic microorganisms. The antimicrobial activities of honokiol and magnolol was evaluted with minimum inhibition concentration. Honokiol was more active than magnolol, but less than chlorhexidine on antimicrobial activity. The inhibitory effects of magnolol and honokiol on the collagenolytic activity and cytotoxicity were evaluated using a Collagenokit CLN-100 and rapid colorimetric assay (MTT method) for cellular growth and survival of gingival fibroblast and periodontalligament cell and