Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis of N-Hydroxy-${\alpha}$-Amino Acid Esters

N-히드록시-${\alpha}$-아미노산 에스테르의 합성

  • Seo, Min-Hyo (Department of Chemistry, Seoul National University) ;
  • Wang, Han-Cheol (Department of Chemistry, Seoul National University) ;
  • Lee, Youn-Young (Department of Chemistry, Seoul National University) ;
  • Goo, Yang-Mo (Department of Pharmacy, Seoul National University)
  • 서민효 (서울대학교 자연과학대학 화학과) ;
  • 왕한철 (서울대학교 자연과학대학 화학과) ;
  • 이윤영 (서울대학교 자연과학대학 화학과) ;
  • 구양모 (서울대학교 약학대학 약학과)
  • Published : 1993.09.20
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Abstract

N-Arylmethylideneglycine N-oxide alkyl esters(1) were alkylated with alkyl halides in THF using lithium hexamethyldisilazide as a base, followed by hydroxylaminolysis to give N-hydroxy-${\alpha}$-amino acid esters(7).

N-Arylmethylideneglycine N-oxide alkyl esters(1)를 THF 용매내에서 lithium hexamethyldisilazide로 처리한 다음 할로겐화 알킬과 반응시켜 알킬화하고 이를 히드록실아민으로 분해시켜 N-hydroxy-${\alpha}$-amino acid esters(7)를 합성하였다.

Keywords

References

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