Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Substitution Reactions of Cyanopyridines with Organometallics

유기금속화합물에 의한 Cyanopyridines의 치환반응에 관한 연구

  • Kim, Jung-Gyun (Department of Chemistry, Pusan National University) ;
  • Yu, Dong-Sik (Department of Chemistry, Pusan National University) ;
  • Moon, Sung-Hwan (Department of Chemistry, Pusan National University) ;
  • Park, Jin-Il (Department of Chemistry, Pusan National University) ;
  • Park, Won-Woo (Department of Chemistry, Pusan National University)
  • 김정균 (부산대학교 자연과학대학 화학과) ;
  • 유동식 (부산대학교 자연과학대학 화학과) ;
  • 문성환 (부산대학교 자연과학대학 화학과) ;
  • 박진일 (부산대학교 자연과학대학 화학과) ;
  • 박원우 (부산대학교 자연과학대학 화학과)
  • Published : 1993.09.20
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Abstract

3-Cyanopyridine, when treated with organolithium or Grignard reagents, gives addition to the 6-position and provides a series of 2-substituted 5-cyanopyridines (6-substituted 3-cyanopyridines). Alternatively, 2-and 4-cyanopyridine react with $CH_3Li$ or $CH_3Mgl$ and provide 2-acetylpyridine and 4-acetylpyridine, respectively.

3-Cyanopyridine을 organolithium 나 Grignard 시약과 반응시키면 6-위치에 첨가반응이 일어나 2-치환된 5-cyanopyridine류(6-치환된 3-cyanopyridine류)가 합성되었다. 반면, 2- 또는 4-cyanopyridine을 $CH_3Li$이나 $CH_3Mgl$와 반응시키면, 각각 2-acetylpyridine과 4-acetylpyridine이 합성되었다.

Keywords

References

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