Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity

  • Kim, Jack C. (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Park, Jin Il (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Hur, Tae-Ho (Department of Chemistry, College of Natural Science, Pusan National University)
  • Published : 1993.04.20
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Abstract

A series of 4-(2-chloroethyl)nitrosocarbamoyl- and 4-methyl nitrosocarbamoyl analogs of 4-Aza-$5{\alpha}$-cholestane (5a and 5b), 4-Aza-5-cholestene (6a and 6b) were synthesized and evaluated for their inhibitory activity against the Sarcoma 180 cell. The steroidal nitrosoureas, 5a, 5b, 6a and 6b displayed modest activity in vitro.

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References

  1. J. Med. Chem. v.6 T. P. Johnston;G. S. McCaleb;J. A. Montgomery
  2. J. Med. Chem. v.15 F. I. Carroll;A. Philip;J.T. Blackwell;D. J. Taylor;M. E. Wall
  3. J. Med. Chem. v.22 H-Y. P. Lam;A. Begleiter;G. J. Galdenberg;C. H. Wong
  4. Arch. Pharm. Res. v.9 J. C. Kim;S. K. Choi;S. H. Moon
  5. Yakhak Hoeji v.29 J. C. Kim;I. S. Choi;D. S. Yu;S. H. Ryu;K. H. Moon
  6. J. Org. Chem. v.26 N. J. Doorenbos;L. C. Huang
  7. J. Pharm. Sci. v.63 N. J. Doorenbos;J. C. Kim
  8. J. Med. Chem. v.9 T. P. Johnston;G. S. McCaleb;P. S. Oliger;J. A. Montgomery

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