Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Cephalosporins Having a Heterocyclic Group at the C-3 Position

  • Myung Hee Jung (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Kul-Woong Cho (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Wan Joo Kim (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Joon-Seob Shin (Yungjin Pharm. Co., LTD.) ;
  • Choong Sil Park (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology)
  • Published : 1993.02.20
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Abstract

3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.

Keywords

References

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Cited by

  1. ChemInform Abstract: Synthesis of Cephalosporins Having a Heterocyclic Group at the C-3 Position. vol.24, pp.46, 1993, https://doi.org/10.1002/chin.199346258