Bulletin of the Korean Chemical Society

  • 제14권1호
  • /
  • Pages.32-38
  • /
  • 1993
  • /
  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis of Cephalosporins Having a Heterocyclic Group at the C-3 Position

  • Myung Hee Jung (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Kul-Woong Cho (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Wan Joo Kim (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology) ;
  • Joon-Seob Shin (Yungjin Pharm. Co., LTD.) ;
  • Choong Sil Park (Antimicrobial Research Lab., Korea Research Institute of Chemical Technology)
  • 발행 : 1993.02.20
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초록

3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.

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참고문헌

  1. Heterocyles v.7 R. Scartazzini;H. Bickel
  2. J. Med. Chem. v.18 R. R. Chauvette;P. A. Pennington
  3. Program, and Abstracts of the 30th Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstr. D. Ikeda;S.-P. Huang;Y. Koyama;M. Hamada;S. Kondo;T. Takeuchi
  4. J. Org. Chem. v.44 K. F. Bernady;M. B. Floyd;J. F. Poletto;M. J. Weiss
  5. Synthesis G. Piancatelli;A. Scettri;M. D'Auria
  6. J. Antibiotics v.38 H. Yamanaka;T. Chiba;K. Kawabata;H. Takasugi;T. Masugi;T. Takaya
  7. US Patent 4,423,213,27 T. Takaya;H. Takasugi;T. Masugi;H. Yamanaka;K. Kawabata
  8. Helv. Chim. Acta. v.58 H. Peter;B. Mueller;H. Bickel
  9. Recent Advances in the Chemistry of ${\beta}$-Lactam Antibioticsββ A. H. Shingler;N. G. Weir;J. Elks(ed.)
  10. J. Antibiotics v.40 T. Naito;H. Hoshi;S. Aburaki;Y. Abe;J. Okumura;K. Tomatsu;H. Kawaguchi
  11. J. Org. Chem. v.42 M. Miyashita;A. Yoshikoshi;P. A. Grieco
  12. J. Amer. Chem. Soc. v.93 S. J. Rhoads;J. M. Watson
  13. J. Org. Chem. v.52 A. B. Reitz;S. O. Nortey;B. E. Maryanoff
  14. NMR-Spektroskopie H. Guenther
  15. Bull. Korean Chem. Soc. v.8 C. H. Lee;C. J. Moon;K. S. Kim;J. H. Kim;D. W. Kim

피인용 문헌

  1. ChemInform Abstract: Synthesis of Cephalosporins Having a Heterocyclic Group at the C-3 Position. vol.24, pp.46, 1993, https://doi.org/10.1002/chin.199346258