Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Effect of Coptis Rhizoma on Benzo (a) pyrene-Induced Hepatotoxicity

Benzo(a)pyrene 에 의해 유도된 간장해에 미치는 황련 수침액의 영향

  • Yoon, Soo-Hong (Dept. of Hygienic Pharmacy, Hyosung Women's University) ;
  • Ha, Hun (Dept. of Hygienic Pharmacy, Hyosung Women's University) ;
  • Seo, Min-Ji (Dept. of Hygienic Pharmacy, Hyosung Women's University)
  • 윤수홍 (효성여자대학교 약학대학 위생약학 교실) ;
  • 하헌 (효성여자대학교 약학대학 위생약학 교실) ;
  • 서민지 (효성여자대학교 약학대학 위생약학 교실)
  • Published : 1993.04.01
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Abstract

The present study was undertaken to find a protective effect of Coptis Rhizoma Extract on liver injury induced by benzo(a)pyrene in rats. This crude drug significantly suppressed the increase of several biochemical parameters such as transaminase, lactate dehydrogenase and alkaline phosphatase in serum and liver and total cholesterol. But there were little changes in elevated serum phospholipid level. The results suggested that Coptis Rhizoma prevent bezo(a)pyrene-induced hepatic injury.

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