Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Dietary Vitamin E on Lipid Metabolism in Caffeine-Fed Rats

카페인 첨가식이로 사육한 흰쥐의 지질대사에 미치는 식이성 비타민 E의 영향

  • 박미리 (상지전문대학 식품영양과) ;
  • 조수열 (영남대학교 식품영양학과)
  • Published : 1993.12.01
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Abstract

This study was designed to investigate the effect of dietary vitamin E levels on lipid metabolism in caffeine-fed rats. Male Sprague-Dawley rats were fed on diet containing one of three levels of vitamin E(37.5, 750, or 1,500mg/kg diet0 which was with or without 0.3% caffeine. The rats were sacrificed after 5 and 10 weeks of the feed periods. Results obtained from this study were as follows ; Net weight gain, feed intake and FER in the caffeine added groups were significantly decreased as compared to those of only vitamin E fed group. Liver and kidney weights tended to increase in the caffeine added groups, but spleen and heart weights were not affected. Total lipid contents in serum and liver tended to decrease as dietary vitamin E became increasing and caffeine diet adding. Serum total cholesterol content tended to increase in the caffeine added group. But, liver cholesterol content were decreased. And the higher the dietary vitamin E level became, the lower serum and liver cholesterol contents were. Serum and liver triglyceride contents were significantly lower in the caffeine added groups than in the only vitamin E fed groups. The degree of decrease was more evident as dietary vitamin E level became more increasing. Serum aminotransferase activity was not affected in all experimental groups.

식이성 비타민 E의 급여수준이 카페인을 투여한 흰쥐의 지질대사에 미치는 영향을 검토하고자, 카페인을 무첨가 또는 0.3% 첨가시킨 식이에 비타민 E를 각각 세가지 급여수준(37.5, 750 및 1,500mg/kg diet)으로 사육기간을 5주와 10주로 하여 사육한 결고는 다음과 같다. 체중증가량, 식이섭취량 및 식이효율은 카페인 급여군에서 비타민 E 단독부여군에 비해 유의하게 감소하였고, 체중 100g당 간과 신장의 중량은 카페인 첨가군에서 유의한 증가를 보였다. 혈청과 간의 total lipid 함량은 카페인 첨가군에서 비타민 E 급여수준을 증가시킬수록 감소하였다. 혈청중 cholesterol함량은 카페인을 첨가하였을 때는 증가하였으나, 간장중 cholesterol의 함량은 비타민 E의 급여수준을 증가시킴에 따라 감소하는 경향이었다. Triglyceride함량은 혈청과 간 모두 카페인 첨가군에서 유의하게 감소하였으며, 그 감소의 정도는 비타민 E 급여수준이 증가할수록 크게 나타났다. 또 혈청 alanine aminotransferase와 aspartate aminotransferase의 활성은 모든 실험군에서 유의한 차이가 없었다.

Keywords

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