한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
- 제8권4호
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- Pages.189-193
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- 1993
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- 1229-1153(pISSN)
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- 2465-9223(eISSN)
Cisplatin의 신장독성에 관한 연구
Studies on the Cisplatin Nephrotoxicity
초록
Cisplatin is useful for various cancers including advanced testicular and ovarian cancers. However, clinical use of cisplatin has been limited due to its dose-related neplrotoxicity. Transport studies across the membrane vesicles were performed to study the cisplatin nephrotoxicity. In these experiments, after cisplatin was administered to adult male New Zealand White rabbits, basolateral membrane (BLM) vesicles were prepared from the renal cortex. Para-aminohippurate (PAH) uptakes through BLM vesicles were measured to examine the interactioln of cisplatin on the transports of the substrates. As results of the uptake experiments using the vesicle systems, cisplatin had little effects on PAH transport through BLM vesicle. In conclusion, cisplatin did not cause the damage of basolateral membranes.