한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제21권2호
  • /
  • Pages.139-143
  • /
  • 1993
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Streptomyces sp. 20747이 생산하는 Tyrosinase-Inhibiting Isoflavonoids

Tyrosinase-Inhibiting Isoflavonoids Produced by Streptomyces sp. 20747

  • 이충환 (KIST 유전공학연구소 미생물공학연구실) ;
  • 전효곤 (KIST 유전공학연구소 미생물공학연구실) ;
  • 고영희 (KIST 유전공학연구소 미생물공학연구실) ;
  • 서영배 (KIST 유전공학연구소 미생물공학연구실)
  • 발행 : 1993.04.01
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초록

Three isoflavonoids having tyrosinase-inhibiting activity were isolated from the culture filtrate of Streptomyces sp. 20747. Their structures were determined by UV, EI-MS, 1H-NMR, 13C-NMR to be daidzein, daidzein 7-rhamnoside, and genistein 7-rhamnoside, which were competitive with substrate and had IC50 value of 14, 19, and 16 ng/ml, respectively to mushroom tyrosinase and did not inhibit melanin production of Streptomyces bikiniensis. Soybean meal as well as peptone were found to be a good nitrogen source for tyrosinase-inhibiting isoflavonoids production, susgesting that soybean meal is not the origin of tyrosinase inhibiting isoflavonoids formation in Streptomyces sp. 20747 strain.

키워드

참고문헌

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