Studies on Biocompatible Membranes (II)-Biocompatibility of Poly(acrylonitrile) Copolymers with Phosphonolipid Polar Groups -

생체적합성 고분자모에 관한 연구(II) -인지질기를 가진 Poly(acrylonitrile) 공중합체의 생체적합성-

A methacrylate monomer having the phosphonolipid polar group, 2-(methacryloxy)ethyl-2-(trine-thylammonium)ethyl phosphate(MTP) was prepared and copolymerized with acrylonitrile(AN) and glycidyl methacrylate(GMA). The polymer membranes and enzyme immobilized membranes were prepared from the copolymers by a solution casting technique. Amounts of protein adsorption on polymer surface were investigated using sorption method. Protein adsorption on the surface of the copolymer with phosphonolipid group was suppressed effectively. In platelet adhesion tests. The copolymer with a phosphonolipid group displayed less platelet adhesion than homopolymers, poly(acrylonitrile), poly (hydroxyethyl methacylate) and Cuprophane. The current reproducibility of glucose sensor was obtained using various glucose solutions. The current was reproducible within 40 hr in the presence of plasma proteins.