Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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EFFECTS OF TUMOR NECROSIS FACTOR-ALPHA ON CYTOCHROME P-450-DEPENDENT DRUG METABOLISM IN PRIMARY MOUSE HEPATOCYTES CULTURES AND MOUSE HEPATOMA CELLS

  • Jung, Hyun-Ho (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Jeong, Hye-Gwang (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Lee, Michael (Department of Life Science, Kwangju Institute of Science and Technology)
  • Published : 1993.12.01
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Abstract

Previous results from several laboratories have demonstrated that tumor necrosis factor-alpha (TNFalpha) depressed cytochrome P-450 (P-450)-dependent drug metabolism in vivo. However, there is some debate whether the action of TNFalpha is mediated by its direct effects on hepatocytes, or is indirectly mediated through the release of other mediators like IL-1 from macrophages. In the present studies, we investigated the effects of TNFalpha on P-450-dependent drug metabolizing enzyme as measured by 7-ethoxyresorufin O-deethylase (EROD) activity.

Keywords

References

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