YAKHAK HOEJI (약학회지)
- Volume 37 Issue 5
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- Pages.538-543
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
The Effect of Betaine on the $CCI_4$ -Induced Hepatotoxicity in Rats
사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과
- Kim, Sun-Yeou (College of Pharmacy, Seoul National University) ;
- Kim, Hong-Pyo (College of Pharmacy, Seoul National University) ;
- Lee, Mi-Kyeong (College of Pharmacy, Seoul National University) ;
- Byun, Soon-Jeong (College of Pharmacy, Seoul National University) ;
- Kim, Seung-Hee (National Institute of Safety Research) ;
- Moon, Aree (National Institute of Safety Research) ;
- Han, Hyung-Mi (National Institute of Safety Research) ;
- Huh, Hoon (College of Pharmacy, Seoul National University) ;
- Kim, Young-Choong (College of Pharmacy, Seoul National University)
- 김선여 (서울대학교 약학대학) ;
- 김홍표 (서울대학교 약학대학) ;
- 이미경 (서울대학교 약학대학) ;
- 변순정 (서울대학교 약학대학) ;
- 김승희 (국립보건안전연구원) ;
- 문애리 (국립보건안전연구원) ;
- 한형미 (국립보건안전연구원) ;
- 허훈 (서울대학교 약학대학) ;
- 김영중 (서울대학교 약학대학)
- Published : 1993.10.01
Abstract
Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-0-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.
Keywords
- Liver-weight/body-weight ratio;
- carbon tetrachloride;
- cytochrome P-450;
- 7-ethoxycoumarin-O-deethylase;
- fatty liver;
- glutathione-S-transferase;
- glutamic pyruvic transaminase