YAKHAK HOEJI (약학회지)
- Volume 37 Issue 5
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- Pages.511-519
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Swelling and Drug Release Characteristics of PVP Hydrogel Polymerized by $\gamma$ -Irradiation Method
김마선 조사법으로 합성한 PVP하이드로겔의 팽윤과 약물방출특성
Abstract
The short and variabke transit of drug throught GI tracj and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and y-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2, 2'-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at
Keywords
- Hydrogel;
- PVP;
- swelling;
- release;
- proxyphylline;
- flurbiprofen;
- chemical method;
- $\gamma$-irradiation method;
- acrylation;
- albumin;
- gastric emptying