YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Antimicrobial activity and tumor cell growth inhibition of an Actinomycete isolated from Korean soil

토양에서 분리한 방선균의 항균력 및 암세포주 성장 억제능

  • Han, Jin-HO (Department of Microbiology, College of Natural Science, Dankook University) ;
  • Kim, Seung-Cheol (Department of Microbiology, College of Natural Science, Dankook University) ;
  • Chang, Young-Soo (Department of Microbiology, College of Natural Science, Dankook University) ;
  • Ryeom, Kon (Department of Microbiology, College of Natural Science, Dankook University)
  • 한진호 (단국대학교 자연대학 미생물학과) ;
  • 김승철 (단국대학교 자연대학 미생물학과) ;
  • 장영수 (단국대학교 자연대학 미생물학과) ;
  • 염곤 (단국대학교 자연대학 미생물학과)
  • Published : 1993.08.01
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Abstract

An Actinomycetes strain JB isolated from Mt. Hanla had a strong antimicrobial activity against gram positive bacteria and tumor cell growth inhibition. Especially, it couldn't degrade starch and casein as organic compounds. It was resist on lincomycin and rifampicin. The spore mass of strain JB which was arethrospore was white. DAP of the cell wall was L, L-DAP. Antimicrobial material was heat stable, dissolved in ethyl acetate, and not dissolved in butanol. In the pressnce of 0.1% phenol and 4% sodium chloride, strain JB could grow, but it didn't growth at below $10^{\circ}C$. Strain JB didn't use dextran, sodium acetate and sodium citrate as sole carbon source and L-cystein and L-thereonine as nitrogen source. The filtered broth of strain JB had the antimicrobial activity against gram positive bacteria, especially Staphylococcus aureus (ATCC 65389) and the growth inhibition of tumor cell line.

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