YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Indentification of Some Metabolites of Carbinoxamine in Rat Urine

흰쥐 뇨에서의 Carbinoxamine의 대사체 확인

  • 정병화 (한국과학기술원 도핑콘트롤센터) ;
  • 이선화 (한국과학기술원 도핑콘트롤센터) ;
  • 김태욱 (한국과학기술원 도핑콘트롤센터) ;
  • 정봉철 (한국과학기술원 도핑콘트롤센터) ;
  • 박종세 (한국과학기술원 도핑콘트롤센터)
  • Published : 1993.08.01
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Abstract

The metabolic profile of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyi-methoxy] N, N-dimethylethanamine, was determined in rat urine. Urinary extracts obtained with or without enzyme hydrolysis were derivatized with MSTFA/TMSCI (N-methyl-N-trimethylsilyl trifluoroacetamide/Trimethylchlorosilane) and analyzed by GC/MSD. In rat urine, which obtained after oral treatment with carbinoxamine maleate, chlorobenzolyl pyridine, (4-chlorophenyl)-2-pyridinyl methanol : carbinol, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N-methylethanamine : norcarbinoxamine, 2-[(4-chlorophenyl)2-pyridinylmethoxy]ethanamine : bis-norcarbinoxamine and parent carbinoxamine were detected in free form. Norcarbinoxamine and bisnorcarbinoxamine were also detected in conjugated form(acetylation). These data suggest that in the rat, hydroxylation of either the benzyl or pyridinyl ring can occur during carbinoxamine elimination. O-demethylation and subsequent conjugation represents the primary pathway of carbinoxamine elimination in the rat.

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