약학회지 (YAKHAK HOEJI)
- 제37권3호
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- Pages.228-234
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- 1993
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- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
7-데아자퓨린 유도체의 합성
Synthesis of 7-Deazapurine Derivatives
초록
A new series of 7-deazapurine derivatives[7,8] as purine antagonists was prepared. Diethyl 4-cyano-N-(diphenyimethylene)-3-arylglutamate[3] were synthesized by LDA-catalyzed Michael addition of N-(diphenylrnethylene)glycine ethyl ester with (E)-2-cyano-3-arylacrylate. Deprotection yields diethyl 4-cyano-3-arylglutamate, which were easily cyclized to 4-cyano-2-ethoxycarbonyl-5-oxo-3-arylpyrrolidine[4]. The compounds[4] were treated with NaBH
키워드
- Purine antagonist;
- LDA-catalyzed Michael addition;
- 4-Cyano-2-ethoxycarbonyl-5-oxo-3-arylpyrrolidine;
- 4-Cyano-5-ethoxy-2H-2-ethoxymethyl-3-aryl-3,4-dihydropyrrole;
- 7-Aryl-6-amino-8-ethoxymethyl-7,8-dihydro-7(3H, 9H)-deazapurine-2-thione;
- 7-Aryl-2,6-diamino-8-ethoxymethyl-7,8-dihydro-7(9H)-deazapurine;
- neoplastic disease;