Archives of Pharmacal Research
- Volume 16 Issue 4
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- Pages.343-346
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 7-[p-(Methylthio)benzoyl]-5-benzofurancetic Acid
- Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
- Geum, Dek-Hyun (Department of Chemistry, Dongeui University) ;
- Kowan, Youn-Sil (Department of Chemistry, Dongeui University) ;
- Son, Byeng-Wha (Department of Chemistry, National Fisheries University of Pusan)
- Published : 1993.12.01
Abstract
A new method was described for the preparation of 7-[p-(methylthio)benzoyl]-5-benzofuranacetic acid 6, which is an analgestic agent. Methyl 5-(2, 3-di-hydobenzofuran)acetate 3 was obtained by Friedel-Crafts reaction of 2, 3-dihydrobenzofuran with methyl .alpha.-chloro-.alpha.(methylthio)actate 1 and desulfurization of 2. Tifurac 6 was synthesized from acylation of 3 with p-(methythio)benzoyl chioride followed by bromination of 4, dehydrohalogenation, and hydrolysis of 5.
Keywords
- 7-[p(Methylthio)-benzoyl]-5-benzofuranacetic acid;
- Analgesic agent;
- Methyl 5-(2,3-dihydrobenzofuran)acetate;
- Friedel-Crafts reaction;
- Methyl $\alpha$-chloro-$\alpha$-(methylthio)acetate