Archives of Pharmacal Research
- Volume 16 Issue 4
- /
- Pages.339-342
- /
- 1993
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Antiviral Activity of Triterpenoid Derivatives
-
Ryu, Shi-Yong
(Korea Research Institute of Chemical Technology)
;
-
Lee, Chong-Kyo
(Korea Research Institute of Chemical Technology)
;
- Ahn, Jong-Woong (Korea Research Institute of Chemical Technology) ;
- Lee, Seung-Ho (Korea Research Institute of Chemical Technology) ;
- Zee, Ok-Pyo (Colllege of Pharmacy, SungkyunKwan University)
- Published : 1993.12.01
Abstract
3-Oxo or/and 11-oxo derivatives of natural 3-hydroxy triterpense, i.e., 3-oxoursolic acid la, 11-oxoursolic acid lb, 3, 11-dioxoursolic acid ic, 3-oxobetulinic acid lla and 3-oxopomolic acid Via were exhibited to show an increased anti-HSV-1 activity in vitro, four to ten times as much as corresponding parent 3-hydroxy compounds.
Keywords
- 3-Oxoursolic acid;
- 3-Oxobetulinic acid;
- 11-Oxoursolic acid;
- 3-Oxopomolic acid;
- 3,11-Dioxoursolic acid;
- 3-Oxoglycyrthetinic acid;
- Antiviral;
- HSV-1