Archives of Pharmacal Research
- 제16권2호
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- Pages.83-88
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Opioid Pure Agonists on the Excitibility of Frog Sciatic Nerve Fibers
- Lee, Jong-Hwa (Dept. of Pharmacy, Sahmyook University) ;
- Frank, George-B. (Dept. of Pharmacology, University of Alberta, Faculty of Medicine)
- 발행 : 1993.06.01
초록
opioid pure agonists, morphine, meperidine and methadone, were used to investigate the effect on the opioid receptor of fron sciatic nerve fibers using sucrose gap apparatus. When applied extracellularly by perfusion, morphine, methadone and meperidine significantly depressed the amplitude of the action potential in frog sciatic nerve fibers as a dose-dependent
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