Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Effect of Radiotherapy on the Ascorbate (Vitamin C) Levels in Whole Blood and Plasmas

방사선 조사가 체내 아스코베이트(비타민 C)농도에 이치는 영향

  • Choi, Gyu-Young (Department of Therapeutic Radiology, Gyeongsang National University, College of Medicine, Gyeongsang Institute of Cancer Research) ;
  • Yoon, Sang (Department of Pediatrics, Gyeongsang National University, College of Medicine, Gyeongsang Institute of Cancer Research)
  • 채규영 (경상대학교 의과대학 치료방사선과학교실,경상대학교 암연구소) ;
  • 윤회상 (경상대학교 의과대학 소아과학교실)
  • Published : 1993.12.01
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Abstract

The role of ascorbate as an antioxidant in the prevention and cure of disease that result from free radicals has been of considerable interest and controversy lately. As an antioxidant, we can expect it to protect against radiation damage caused by free radicals that are produced when radiation, especially sparsely ionizing radiation, interacts with living tissues. The plasma and whole blood concentration of ascorbate was analyzed before and just after the radiation therapy for the purpose of estimating the consumption amount of ascorbate during radiotherapy. Whole blood ascorbate was decreased from 1.82 mg/dl to 1.58 mg/dl, plasma ascorbate was decreased from 1.13 mg/dl to 1.08 mg/dl, and urine ascorbate was decreased from 9.33 mg/dl to 6.96 mg/dl after radiotherapy. Although the difference was not significant statistically, further human study should be followed to define the role of ascorbate as a radioprotector.

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