An Experimental Study on the Change of Stress-related hormone Contents by Prescription of Kyogamdan and Sohaphyangwon

교감단(交感丹)과 소합향원(蘇合香元) 투여후(投與後) 항(抗) STRESS 관련(關聯) HORMONE 함량(含量) 변화(變化)에 대(對)한 실험적(實驗的) 고찰(考察)

  • 김기대 (경산대학교 한의과대학 신경정신과학교실) ;
  • 정대규 (경산대학교 한의과대학 신경정신과학교실)
  • Published : 1993.07.07

Abstract

This study was conducted in order to study the anti-stress effect of Kyogamdan and Sohaphyangwon, and the changes of serum catecholamine, aldosterone and cortisol levels were measured. In this study author gave immobilization stress to rats and got the following results. 1. The contents of norepinephrine in control group were 4.26 ${\pm}$ 0.50, 3.72 ${\pm}$ 0.31ng/ml 3hr, 6hr after an oral administration of Nacl, but in sample A the contents were 3.12 ${\pm}$ 0.33, 3.20 ${\pm}$ 0.41ng/ ml and in sample B were 3.50 ${\pm}$ 0.65, 2.49 ${\pm}$ 0.55ng/ ml. The difference was obvious. 2. The contents of epinephrine in control group were 7.01 ${\pm}$ 0.85, 6.50 ${\pm}$ 0.68ng/ ml after 3hr, 6hr since Nacl was taken, but in sample A the contents were 4.95 ${\pm}$ 0.67, 4.45 ${\pm}$ 0.58ng/ ml and in sample B were 5.87 ${\pm}$ 0.87, 4.33 ${\pm}$ 0.59ng/ ml. The real significance lies in 6hr after administration of Sample A and B. 3. The contents of cortisol in control group were 3.39 ${\pm}$ 0.04, 3.73 ${\pm}$ 0.04ng / ml, but in sample A were 2.99 ${\pm}$ 0.02, 4.74 ${\pm}$ 0.04, and in sample B were 2.69 ${\pm}$ 0.03, 3.79 ${\pm}$ 0.03ng / ml. The real significance lies in 3hr since sample A and B were taken. 4. The aldosterone contents in control group were 1121.90 ${\pm}$ 71.90, 1454.30 ${\pm}$ 168.50 pg / ml, but in sample A were 1198.20 ${\pm}$ 69.10, 1257.50 ${\pm}$ 180.70 and in sample B were 776.30 ${\pm}$ 79.10, 1367.00 ${\pm}$ 170.10 pg / ml. The real significance lies in 3hr Sample B was taken. Base on the results above, it may be concluded that Kyogamdan and Sohaphyangwon are effective to prevent the changes by stress and Sohaphyangwon is better effective than Kyogamdan to prevent stress.

Keywords

References

  1. 診療要鑑 金定濟
  2. 病理學 文濬典;安圭錫;崔昇勳(共著)
  3. 萬病回春 공延賢
  4. 醫學入門 李천
  5. 方證新編 宋炳基
  6. 氣란 무엇인가 박희준(옮김);丸山敏秋(著)
  7. 方藥合編解說 申載鏞
  8. 東醫病理學總論 安圭錫(編著)
  9. 東醫處方大典 廉泰煥
  10. 東醫臨床方劑學 尹吉榮
  11. 本草學 李尙仁
  12. 醫門寶鎰 周命新(編著)
  13. 方藥合編 黃度淵
  14. 心身症 黃義完
  15. 東醫寶檻 許俊
  16. 경희대학교 대학원 학위논문 祛痰淸心湯의 抗 Stress 效果에 대한 實驗的 硏究. 金基玉
  17. 경희대학교 대학원 학위논문 牛黃淸心丸과 蘇合香元의 效能 에 關한 硏究. 南相璟
  18. 월간한의학 no.6 補血安神湯 加味補血安神湯의 抗 stress 效果에 關한 實驗的 硏究 李東鑽
  19. 대구한의과대학 대학원 학위논문 三和散의 抗 Stress 및 鎭痛 에 對한 實驗的 硏究 李和信
  20. 대구한의과대학 대학원 학위논문 分心氣飮 投與에 따른 Stress 關聯 Hormone의 含量變化에 關한 實驗的 考察 池鮮英
  21. 方劑學 上海中醫學院編
  22. 中草藥學 上海中醫學院編
  23. 醫學門徑 徐學山
  24. 黃帝內經 靈樞譯解 楊維傑
  25. 外臺秘要 王燾
  26. 醫宗必讀 李中梓
  27. 萬病 醫學順問(上) 陸靑節
  28. 本草三家合註 張隱庵(外)
  29. 醫學心悟 程國彭
  30. 太平惠民和劑局方 陳師文
  31. The wisdom of the body Cannon, W. B
  32. Methods in Enzymology v.142 Catecholamine measurements in Plasma by high performance liquld chromatogra-phy with electrochemical detection Hjemdahl. P.(et al.)
  33. J. Clin. Endocr. Metab. v.45 A non-chroma-tographic non-extraction radio- im-munoassay for serum aldosterone. Ogihara, T.(et al)
  34. The stress of life Selye. H
  35. In principles of compeitive binding assays Yallow, C. T.(et al) Odell;Daughabay(eds)