Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antimutagenic effects of 4-decanol identified from mustard leaf

갓으로부터 분리, 동정된 4-decanol의 항돌연변이 효과

  • Kim, Jeong-Ok (Department of Chemistry, Pusan Women's University) ;
  • Kim, Mu-Nam (Department of Food Science and Nutrition, Pusan Women's University) ;
  • Park, Kun-Young (Department of Food Science and Nutrition, Pusan National University) ;
  • Moon, Suk-Hee (Department of Food Science and Nutrition, Pusan National University) ;
  • Ha, Yeong-Lae (Department of Agricultural Chemistry, Gyeong Sang National University) ;
  • Rhee, Suk-Hee (Department of Food Science and Nutrition, Pusan National University)
  • 김정옥 (부산여자대학교 화학과) ;
  • 김무남 (부산여자대학교 식품영양학과) ;
  • 박건영 (부산대학교 식품영양학과) ;
  • 문숙희 (부산대학교 식품영양학과) ;
  • 하영래 (경상대학교 농화학과) ;
  • 이숙희 (부산대학교 식품영양학과)
  • Published : 1993.12.31
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Abstract

The chloroform extract of mustard leaves (Brassica juncea Cosson) reduced mutagenicity of $AFB_1$ in bacterial assay (Salmonella typhimurium TA100). 4-Decanol was one of major compounds in the chloroform extract when analyzed by GC-MS on HP-5 capillary column. The authentic compound of 4-decanol dissolved in DMSO (0.5%) inhibited mutagenic activities of $AFB_1$ and MNNG in Salmonella typhimurium TA100 at a rate of 99% and 93%, respectively. This result indicates that 4-decanol is an antimutagenic compound present in chloroform extract of mustard leaves.

갓(Brassica juncea Cosson)의 chloroform추출물이 Salmonella typhimurium TA100균주에서 $AFB_1$의 돌연변이유발을 억제시키는 효과가있었으며, chloroform획분 중에 존재하는 화합물을 GC-MS로 분리/동정한 결과 4-decanol이 다량으로 함유되어있었다. 4-Decanol을 0.5%되게 DMSO에 녹인용액을 처리하였을 때 대조구에 비해 $AFB_1$과 MNNG의 돌연변이성을 각각 99%와 93%저해효과를 보이므로서 강한 항돌연변이 물질임이 밝혀졌다.

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