Journal of Pharmaceutical Investigation
- Volume 23 Issue 3
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- Pages.41-50
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
The Role of Excipients in Iontophoretic Drug Delivery: In vitro Iontophoresis of Isopropamide and Pyridostigmine through Rat Skin and Effect of Ion-pair Formation with Organic Anions
- Shim, Chang-Koo (Department of Pharmaceutics, College of Pharmacy Seoul National University)
- Published : 1993.09.20
Abstract
The iontophoretic delivery across rat skin of quaternary ammonium salts (isopropamide: ISP, pyridostigmine: PS), which are positively charged over a wide pH range, was measured ill vitro. The study showed that: (a) iontophoresis significantly enhanced delivery of ISP and PS compared to respective passive transport; (b) delivery of ISP and PS was directly proportional to the applied continuous direct current density over the range of
Keywords
- Iontophoresis;
- Isopropamide;
- Pyridostigmine bromide;
- Quaternary ammonium salt;
- Ion-pair complex;
- Counteranions;
- Sodium ion;
- Hydronium ion;
- Permselectivity