Journal of Pharmaceutical Investigation

  • 제23권2호
  • /
  • Pages.89-95
  • /
  • 1993
  • /
  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지

Cholesterol기를 갖는 고분자화된 Vesicle들의 투과 특성

Permeability Characteristics of Cholesterol-Containing Polymerized Vesicles

  • 조의환 (한국과학기술원 서울분원 신소재공학과) ;
  • 배덕환 (충북대학교 자연과학대학 화학과) ;
  • 신재섭 (충북대학교 자연과학대학 화학과)
  • Cho, I-Whan (Department of Advanced Materials Engineering, Korea Advanced Institute of Science and Technology) ;
  • Bae, Duck-Hwan (Department of Chemistry, Chungbuk National University) ;
  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University)
  • 발행 : 1993.06.20
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초록

Polymerized vesicles were prepared from the monomeric cholesterol-containing surfactant. Spacer groups were introduced into [(cholesteryloxy)carbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA). In case of introducing the spacer groups to the cholesterol moiety, both permeability of vesicles and that of polymerized vesicles were decreased. In case of introducing the spacer groups to monomeric moiety, permeability of vesicles was increased, while that of polymerized vesicles was decreased.

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