The Korean Journal of Pharmacology (대한약리학회지)
- Volume 29 Issue 2
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- Pages.225-235
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- 1993
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- 0377-9459(pISSN)
Regulation of $LH{\beta}$ subunit mRNA by Ovarian Steroid in Ovariectomized Rats
난소제거된 흰쥐에서 난소호르몬에 의한 $LH{\beta}$ subunit의 유전자 발현조절
- Kim, Chang-Mee (Department of Biology, Yonsei University) ;
- Park, Deok-Bae (Department of Endocrine Laboratory, College of Medicine, Yonsei University) ;
- Ryu, Kyung-Za (Department of Pharmacology, College of Medicine, Yonsei University)
- Published : 1993.12.30
Abstract
Pituitary LH release has been known to be regulated by the hypothalamic gonadotropin releasing hormone (GnRH) and the gonadal steroid hormones. In addition, neurotransmitters and neuropeptides are actively involved in the control of LH secretion. The alteration in LH release might reflect changes in biosynthesis and/or posttranslational processing of LH. However, little is known about the mechanism by which biosynthesis of LH subunits is regulated, especially at the level of transcription. In order to investigate if ovarian steroid hormones regulate the LH subunit gene expression,
난소호르몬에 의하여 황체형성호르몬(luteinizing hormone; LH) subunit의 유전자 발현이 어떻게 조절되는가를 조사하기 위하여 성숙한 흰쥐에서 난소를 제거하거나 또한 난소호르몬을 재 투여한 후