Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Effect of Platelet Activating Factor on the Secretion of Progesterone in the Rabbit

혈소판 활성인자가 백서의 Progesterone 생성에 미치는 영향

  • Cho, Soo-Hyun (Department of Obstetric and Gynecology, School of Medicine, Hanyang University) ;
  • Chung, Sung-Ro (Department of Obstetric and Gynecology, School of Medicine, Hanyang University) ;
  • Hwang, Yeoun-Young (Department of Obstetric and Gynecology, School of Medicine, Hanyang University) ;
  • Moon, Hyung (Department of Obstetric and Gynecology, School of Medicine, Hanyang University)
  • 조수현 (한양대학교 의과대학 산부인과학교실) ;
  • 정성로 (한양대학교 의과대학 산부인과학교실) ;
  • 황윤영 (한양대학교 의과대학 산부인과학교실) ;
  • 문형 (한양대학교 의과대학 산부인과학교실)
  • Published : 1992.06.30
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Abstract

Platelet activating factor(PAF) has been reported to play a significant role in ovulation, establishment and maintnance of early pregnancy. The object of this study was to investigate the influence of PAF on progesterone secretion in rabbit by measurement of pheripheral blood concentration of progesterone. PAF had no effect on progesterone secretion and did not induce decidual reaction in nonovulatory rabbit. But 8th day of hCG induced pesudopregnant rabbit, PAF significantly increase progesterone secretion. Progesterone level was significantly increased at 0.5 and 4 hours after treatment with $10^{-8}$ M PAF on days 2, 4, 6, 8 of gestation as compared than those treated with normal saline. When PAF was injected 2 days after coitus, progesterone levels on days 4, 6, 10, 14 of gestation was significantly increased than those with saline injected group. These results suggest that PAF increase progesterone secretion from the hCG-primed ovary and during pregnancy in rabbit.

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