Acknowledgement
Supported by : 가톨릭 중앙의료원
Background: Recently, bronchial provocation of the airway of atopic asthmatic subjects with inhaled allergen has been shown to produce an initial peripheral blood eosinopenia followed by an eosinophilia occurring approximately 12 to 18 hrs after the challenge. However there are few studies about the change of peripheral eosinophil count (PEC) after bronchial provocation with nonspecific stimuli such as histamine or methacholine. Interestingly our preliminary study demonstrated a notable change of PEC during bronhial provocation with inhaled histamine in some asthmatic subjects. This study was designed to reevaluate our preliminary data and to further investigate the change of PEC during as well as after bronchial provocation with inhaled histamine in bronchial asthma tics. Methods: Sixteen asthmatic subjects participated in this study. Bronchial provocation with inhaled histamine was done between 9 AM and 12 MD. Blood samplings for PEC were done with 5 minutes intervals during the procedure, and repeated at 1 hour, 2 hours, 4 hours, 8 hours, 24 hours, and 48 hours after the procedure. Results: The results were as follows; 1) The patients were divided into two groups characterized by each pattern in the change of PEC during the procedure. A group (11 of sixten, group I) showed an increasing pattern of PEC and another group (5 of sixteen, group II) showed a decreasing pattern of PEC during the procedure. 2) Group I demonstrated a tendency to maintain continuously higher level of PEC than the baseline value until 48 hours after the procedure. 3) Group II demonstrated a tendency to maintain continuously lower level of PEC than the baseline value until 48 hours after the procedure. 4) There were no significant differences in their clinical parameters including baseline eosinophil count, baseline
연구배경 : 최근 알레르겐 흡입을 이용한 기관지유발 검사시 말초혈액 호산구수의 변화가 있음이 알려져 있고, 이는 기도 조직내로의 호산구 유입과 관련이 있음이 밝혀졌다. 그러나 히스타민나 에타콜린 흡입과 같은 비특이적 자극에 의한 기관지유발시 말초혈액 호산구수의 변화에 대한 연구는 아직 불충분하다. 이에 대해 저자들은 예비적으로 몇몇 천식 환자들을 대상으로 히스타민 기관지유발검사후 기도수축이 일어날때까지 말초혈액 호산구수를 단계적으로 측정해본 결과, 호산구수가 점차로 증가하는 환자군과 반대로 감소하는 환자군이 있음을 관찰하였다. 따라서 본연구에서는 저자들의 이러한 예비연구 결과를 재검토하고, 히스타민 기관지유발 검사중에 나타난 말초혈액 호산구수의 변화가 검사후에는 어떤 경과를 밟게 되는지를 관찰하고자 하였다. 방법 : 16명의 천식 환자를 대상으로 히스타민 기관지 유발검사를 시행함과 동시에, 검사전 및 검사후 노력성 1초 호기량(
Supported by : 가톨릭 중앙의료원