Acknowledgement
Supported by : 교육부
Applied Chemistry for Engineering (공업화학)
- Volume 3 Issue 2
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- Pages.273-279
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- 1992
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- 1225-0112(pISSN)
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- 2288-4505(eISSN)
Synthesis of Polymerized Vesicles for Cholesterol Extraction
콜레스테롤의 추출을 위한 고분자화된 Vesicles의 합성
- Cho, Iwhan (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
- Kim, Sang-Hee (Department of Chemistry, College of Natural Sciences, Chungbuk National University) ;
- Shin, Jae-Sup (Department of Chemistry, College of Natural Sciences, Chungbuk National University)
- Received : 1992.01.10
- Accepted : 1992.03.26
- Published : 1992.06.30
Abstract
Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. A polymerized vesicle was formed both monomeric cholesterol-containing surfactant and monomeric surfactant containing two alkyl chain(50 : 50 weight ratio). This vesicle got the better extracting capacity compared with the vesicle which got the other weight ratio of the surfactants. This vesicle also exhibited the fastest substrate permeability. These all results showed that considerable vacant room is necessary in polymerized vesicles in order to extract more cholesterols.
콜레스테롤을 갖는 계면활성제를 합성하고 중합하여 고분자화된 vesicle들을 얻었으며, 이러한 vesicle들을 이용하여 콜레스테롤을 추출해 내는데 사용하였다. 콜레스테롤을 갖는 계면활성제와 두 개의 알킬사슬을 갖는 계면활성제를 50 : 50으로 혼합하여 vesicle을 형성시킨 후 중합하여 형성된 고분자화된 Vesicle이 각각의 계면활성제들을 사용한 경우와 비교하여 볼 때 콜레스테롤을 효과적으로 추출해 내었다. vesicle의 투과도도 50 : 50으로 혼합하여 형성시킨 경우가 가장 컸다. 그러므로 많은 양의 콜레스테롤을 함유하려면 어느정도의 여유 공간이 필요하다고 결론지을 수 있다.
Keywords